Chemotherapy was potentiated by E7449 and single agent had considerable antitumor action in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, most likely by means of TNKS inhibition. Per this chance, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression of https://sb20219035789.blogginaway.com/29909124/5-tips-about-chrysin-7-o-glucuronide-you-can-use-today