Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have identified recurrent mutations in genes regulating tumor cell-microenvironment intera... https://kirkp653xkx8.oblogation.com/profile