Pentobarbital will lessen the level or effect of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. pentobarbital will lower the extent or outcome of ibuprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Not known. pentobarbital will lower the level or effect of midazolam by influencing hepatic/intestinal enzyme CYP3A4 me... https://genghisi877vxd0.wikipresses.com/user