Interactions with Benzodiazepines and Other CNS Depressants Advise patients and caregivers that potentially deadly additive effects may possibly manifest if acetaminophen and codeine phosphate tablets are used with benzodiazepines or other CNS depressants, including alcohol, and never to work with these drugs concomitantly Except supervised by a healthcare provider (see https://directoryorg.com/listings13188625/not-known-facts-about-codeine-toux