There is a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent pain transmission and deliver analgesia. Thus, drugs like clonidine that goal alpha-two receptors can influence the transmission of ache. Clonidine treats superior hypertension by stimulating αtwo https://www.proleviate.com/post/the-new-pain-killer-conolidine