Finally, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive way, which often can reduce the dose of every ingredient by 60% for postoperative analgesia. For those who get dizzy when standing: This situation is referred to as orthostatic hypotension. Clonidine may make this issue worse. https://madesocials.com/story5287794/onolidine-an-overview