Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors from the central anxious technique, conolidine modulates alternate molecular targets. A Science Advances analyze observed that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://ez-bookmarking.com/story20787620/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers