New selective PAD4 inhibitors binding a calcium-deficient method of the PAD4 enzyme have validated the significant enzymatic purpose of human and mouse PAD4 in the two histone citrullination and neutrophil extracellular lure formation for, to our understanding, The 1st time. The therapeutic opportunity of PAD4 inhibitors can now be explored. https://wardz332obl5.mycoolwiki.com/user